Association of Neuregulin 1 with Schizophrenia Confirmed in a Scottish Population
نویسندگان
چکیده
منابع مشابه
Association between a Missense Polymorphism (rs3924999, Arg253Gln) of Neuregulin 1 and Schizophrenia in Korean Population
Neuregulin 1 (NRG1) is associated with the pathogenesis of schizophrenia through controlling activation and signaling of neurotransmitter receptors. Influence to schizophrenia development by the NRG1 gene may differ in individuals, and genetic polymorphism is one of the factors affecting their differences. Association between three single nucleotide polymorphisms (SNPs) (rs7014762, -1174 A/T; r...
متن کاملassociation between neuregulin-1 gene variant (rs2439272) and schizophrenia and its negative symptoms in an iranian population
objective: although the etiology of schizophrenia is unknown, it has a significant genetic component. a number of studies have indicated that neuregulin-1 (nrg1) gene may play a role in the pathogenesis of schizophrenia. in this study, we examined whether the rs2439272 of nrg1 is associated with schizophrenia and its negative symptoms in an iranian population. method: rs2439272 was genotype...
متن کاملNeuregulin 1 genotype and schizophrenia.
The neuregulin 1 (NRG1) gene has been the subject of considerable excitement within the psychiatric genetics literature since it was originally identified as a potential susceptibility locus for schizophrenia. Here we provide an update of our first meta-analysis of this association. Case-control and family-based genetic association studies of the NRG1 gene in healthy control groups and clinical...
متن کاملNeuregulin 1 and susceptibility to schizophrenia.
The cause of schizophrenia is unknown, but it has a significant genetic component. Pharmacologic studies, studies of gene expression in man, and studies of mouse mutants suggest involvement of glutamate and dopamine neurotransmitter systems. However, so far, strong association has not been found between schizophrenia and variants of the genes encoding components of these systems. Here, we repor...
متن کامل Association Between Neuregulin-1 Gene Variant (rs2439272) and Schizophrenia and Its Negative Symptoms in an Iranian Population
Objective: Although the etiology of schizophrenia is unknown, it has a significant genetic component. A number of studies have indicated that neuregulin-1 (NRG1) gene may play a role in the pathogenesis of schizophrenia. In this study, we examined whether the rs2439272 of NRG1 is associated with schizophrenia and its negative symptoms in an Iranian population. Method: Rs2439272 was genotype...
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ژورنال
عنوان ژورنال: The American Journal of Human Genetics
سال: 2003
ISSN: 0002-9297
DOI: 10.1086/345442